Abstract Search

ea0063p398 | Thyroid 1 | ECE2019

Intellectual outcome in children with subclinical hypothyroidism: effects of two years of levothyroxine treatment

Ciccarelli Gian Paolo , Improda Nicola , Anselmi Federica , Polizzi Miriam , Bravaccio Carmela , Capalbo Donatella , Salerno Mariacarolina

Introduction: Subclinical hypothyroidism (SH) is characterized by serum TSH levels above the upper limit of the reference range, in the presence of normal serum concentrations of total T4 and free T4. Associ-ation between SH in childhood and adverse neurocognitive outcomes remains controversial.Objective: To evaluate the intellectual outcome of children with SH before and after 2 years of treatment with levothyroxine (L-T4).Methods...

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ea0063gp176 | Benign Thyroid Disorders | ECE2019

Do different initial doses of L-T4 within the range of 10–15 mcg/kg/die influence neurodevelopment during the first two years of life in children with congenital hypothyroidism?

Moracas Cristina , Ciccarelli Gian Paolo , Bravaccio Carmela , Cassio Alessandra , Gastaldi Roberto , Mussa Alessandro , Polizzi Miriam , Vigone Maria Cristina , Wasniewska Malgorzata Gabriela , Weber Giovanna , Salerno Mariacarolina

Background: The initial L-T4 dose in the treatment of congenital hypothyroidism (CH) currently recommended is 1015 mcg/kg/die.Objective: We designed a multicenter randomized trial to evaluate the effects of different starting dose of L-T4 within the range 1015 mcg/kg/die on neurocognitive development in children with CH.Methods: Seventy-two children with CH diagnosed by neonatal screening were enrolled in the study. The...

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Endocrine Abstracts

Intellectual outcome in children with subclinical hypothyroidism: effects of two years of levothyroxine treatment

Do different initial doses of L-T4 within the range of 10–15 mcg/kg/die influence neurodevelopment during the first two years of life in children with congenital hypothyroidism?

BiosciAbstracts